To perform the assay of Ibuprofen.

 Experiment

Aim: 

To perform the assay of Ibuprofen.

Structure:

Ibuprofen structure

IUPAC Name:

2-(4-isobutylphenyl) propionic acid.

Molecular Formula: 

 C13H1802

Mol. Weight: 206.28

Theory:

Ibuprofen is (RS)-2-(4-isobutylphenyl) propionic acid.

Ibuprofen Tablets contain not less than 95.0 per cent and not more than 105.0 per cent of the stated amount of ibuprofen, C13H1802. The tablets are coated.

Usual strengths: 200 mg; 400 mg; 600 mg.

Category: Anti-inflammatory, Analgesic.

Dose: 

600 mg to 1.2 g daily, in divided doses, after food.

Description: A white or almost white, crystalline powder or colourless crystals.

Assay:

1. Weight 0.4 gm, dissolve in 100 ml of ethanol (95%) and titrate with 0.1 M sodiumhydroxide using 0.2 ml of phenolphthalein solution as an indicator.

2.Carry out a blank titration.

Factor: 1 ml of 0.1 M sodium hydroxide is equivalent to 0.02063 g of C13H1802.

Storage: 

Store protected from light and moisture.

Uses: 

It is used as anti-inflammatory and analgesic drug.

Reference:

Dr. Abhishek Tiwari, Dr. Rajeev Kumar " A practical book of medicinal chemistry" Nirali Prakashan Pune 2019 pp 64

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