Aim: To prepare and submit Chlorobutanol from acetone.
Reference:
Furnish B.S, Hanford A.J. "Vogel's Textbook of organic chemistry" longmann scientific and technical UK Ltd. 5th edition 1989 pp__
Requirements: Acetone, chloroform, potassium hydroxide, round bottom flask, glass rod,
beaker.
Theory: Chlorobutanol (trichloro-2-methyl-2-propanol) is synthesized by nucleophilic addition of chloroform and acetone. The reaction is base driven by sodium or potassium hydroxide.
Reaction involved:
Procedure:
1.Mix dry acetone (5 g) and chloroform (10 g) with continuous stirring and cool to
below 0°C.
2.Add gradually potassium hydroxide (3.25 g) over a period of 60 hours.
3.Allow to stand at room temperature for a further 36 hours with intermittent stirring.
4.Filter the mass and wash the residue with acetone.
5.The combined filtrates are distilled, unchanged chloroform and acetone are recovered, and the fraction passing over between 165°C and 172°C is collected separately.
6.Pour the distillate in water, crystallization take place and then filter the solid.
7.Recrystallize the product with a mixture of alcohol and water.
8.Melting point of anhydrous chlorobutanol is 96-97°C.
Calculation:
Theoretical yield =
Practical yield =
%yield = Practical yield × 100
Theoretical yield
Results: The yield of obtained product was found to be ....... gm.
Uses: It is used as a preservative, sedative, hypnotic and weak local anesthetic. It has
antibacterial and antifungal properties.
Cautions: Glass ware should be clean and dry before being used. At ordinary temperatures,chlorobutanol is extremely volatile and requires to be dried with great care to avoid loss.
Synthesis of Chlorbutanol.
Chlorbutanol synthesis practical.
Prepration of Chlorbutanol,
Lab prepration of Chlorbutanol
Chlorbutanol from aceton.
0 Comments