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To perform the Assay of Dapsone.

 Experiment

Aim:

 To perform the assay of Dapsone.

Structure:

Dapsone structure, dapsone image,

IUPAC Name:

bis (4-aminophenyl) sulphone

Molecular formula: 

C12H12N2O2S

Mol. Wt.: 248.3

Dapsone contains not less than 99.0% and not more than 101.0% of C12H12N2O2S calculated on the dried basis.

Category: Antileprotic.

Dose:

 100 mg daily.

Description: A white or creamy-white, crystalline powder.

Assay:

1.Dissolve 0.3 gm in a mixture of 20 ml of water and 20 ml of 2 M hydrochloric acid,add 3 gm of potassium bromide.

2.Cool the solution to about 15°C and determine by nitrite titration.

3.Carry out a blank titration.

Factor: 

1 ml of 0.1 M sodium nitrite is equivalent to 0.01242 gm of C12H12N2O25.

Storage: 

Store protected from light.

Uses:

 It is used as antileprotic drug.

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Reference:

Dr. Abhishek Tiwari, Dr. Rajeev Kumar " A practical book of medicinal chemistry" Nirali Prakashan Pune 2019 pp 70.

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Assay of dapsone,

medicinal use of dapsone, 

dose of dapsone.

Storage of dapsone.


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