Experiment:
Aim:
To perform the assay of Chlorpheniramine maleate by titration.
Structure:
IUPAC Name:
3-(4-chlorophenyl)-3 (pyrid-2-yl) propyl
dimethyl amine hydrogen maleate.
Molecular Formula:
C16H19CIN2, C4H404
Mol. Wt.: 390.9 g/mol
Chlorpheniramine maleate contains not less than 98.0 percent and not more than
101.0 percent of C16H19CIN2, C4H4O4, calculated on dried basis.
Category: Antihistaminic.
Dose:
Orally, 4 to 16 mg daily, in divided doses. By subcutaneous or intramuscular injection,
10 to 20 mg, repeated if required; maximum 40 mg in 24 hours. By slow intravenous
injection over 1 minute, 10 to 20 mg diluted in the syringe with 5 to 10 ml of blood.
Description:
A white, crystalline powder; odourless.
Assay:
1.Weigh accurately about 0.2 g and dissolve in 20 ml of anhydrous glacial acetic acid.
2.Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically.
3.Carry out a blank titration.
4.Factor: 1 ml of 0.1 M perchloric acid is equivalent to 0.01954 g of C16H19CIN2, C4H4O4.
Storage:
Store ted from light and moisture.
Uses:
1.It is used as antihistaminic drug.
2.It is also used in allergy caused by pollen grains or by insects bite.
3. Also used in treatment of hay fever, urticaria.
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Assay of chlorpheniramine maleate.
Chlorpheniramine structure,uses, storage.
Chlorpheniramine maleate dose.
Chlorpheniramine maleate assay.
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