Experiment
Object:
Synthesis of triphenyl imidazole from benzil and benzaldehyde.
Reference:
Furnish B.S, Hanford A.J. "Vogel's Textbook of organic chemistry" longmann scientific and technical UK Ltd. 5th edition 1989 pp
Dr. Abhishek Tiwari, Dr. Rajeev Kumar " A practical book of medicinal chemistry" Nirali Prakashan Pune 2019 pp 48
Requirements
Chemical: benzil, ammonium acetate, benzaldehyde, glacial acetic acid
Glassware: RBF, Beaker, glass rod, funnel.
Instruments/Other: filter paper
Principle:
when benzil, ammonium acetate and benzaldehyde reacts in the presence of glacial Acetic Acid it gives out 2,4,5 triphenyl 1-H-imidazole.
Procedure
1.Take benzil (1 gm), ammonium acetate (1 gm), benzaldehyde (2 ml), glacial acetic acid(2 ml) in round bottom flask and reflux for 3 hours.
2.Allow reaction mixture to stand to room temperature to attain room temperature.
3.Add 150 ml of water and filter.
4.The filtrate is neutralized with ammonium hydroxide or sodium carbonate to give solid pasty mass and again filter.
5.Then the solid mass is washed with toluene and recrystallize from methanol.
6.Melting point of 2,4,5-tripheny-1H-imidazole is 274-278°C.
Uses:
It is used as antibacterial and antiinflammatory activities.
Calculations:
Theoretical Yield=
Practical Yield=
% Yield= Practical Yield ×100
Theoretical Yield
Result:
The yield of product was found to be________mg(gm).
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Uses of triphenyl 1H-imidazole
IUPAC Name of triphenyl imidazole.
Medicinal use of triphenyl imidazole.
Structure of triphenyl imidazole,
Synthesis reaction of triphenyl imidazole.
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